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desvenlafaxine will increase the level or impact of codeine by impacting hepatic enzyme CYP2D6 metabolism. Use Warning/Keep an eye on. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) lower the CYP2D6 substrate dose by as much as fifty%; no dosage adjustment wanted with desvenlafaxine doses 7 consecutive days straight away previous to getting alvimopan).

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Steer clear of using codeine in adolescents 12 to eighteen yrs of age who produce other possibility components that may boost their sensitivity to respiratory depressant effects of codeine; risk aspects involve circumstances affiliated with hypoventilation, for instance postoperative status, obstructive slumber apnea, being overweight, intense pulmonary condition, neuromuscular condition, and concomitant utilization of other drugs that cause respiratory melancholy.

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Reserve concomitant prescribing of these prescription drugs in patients for whom other cure alternatives are insufficient. Limit dosages and durations to your minimal demanded. Check intently for signs of respiratory despair and sedation.

Make certain you understand how to consider this products and what other medications it is best to stay away from having with it. See also click here Drug Interactions area. Get clinical assist without delay if any of such quite critical Unwanted effects take place: slow/shallow respiration, unusual lightheadedness, critical drowsiness/dizziness, trouble waking up.

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